"Mujhay Qabool Nahin" delves into the lives of two sisters, Mashaal and Maira, who find themselves bound by their father's decision to marry them to their cousins, Arsalan and Salman. Maira, an ambitious young woman, strives to balance her professional aspirations while taking on her mother's responsibilities. However, her relationship with Salman, an arrogant and inept individual, proves to be a constant source of conflict.